'Otje' tells the story about the eight-year-old Otje and her easily agitated father Tos. They live in the attic of the, almost bankrupt, hotel 'De Koperwiek', where Tos has a job as a cook. Otje is a boyish girl that loves to play outside. She’s got a secret tree-house and is friends with Betsy the cat, Boef the dog and all the birds in the forest. Tos is a bit sceptic about Otje's relationships with animals and doesn't believe that she has the ability to communicate with them.
Otje and her father Tos have a lot of adventures. One day, they are forced to leave their small apartment in the ‘Koperwiek’, the place where Otje loves to live. In the end, it all turns out fine. They find their way back to the hotel by buying it. Now she can live her life like it was before, and has her old animal friends back!